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Systematic Review & Meta-analysis


About Cochrane

Cochrane is a non-profit, non-governmental organization formed to organize medical research findings so as to facilitate evidence-based choices about health interventions faced by health professionals, patients, and policymakers. Cochrane includes 53 review groups that are based at research institutions worldwide. Cochrane has approximately 30,000 volunteer experts from around the world.

The group conducts systematic reviews of health-care interventions and diagnostic tests and publishes them in the Cochrane Library. According to the Library, articles are available via one-click access but some require paid subscription or registration before reading. A few reviews, in occupational health, for example, incorporate results from non-randomized observational studies, as well as controlled before-after (CBA) studies and interrupted time-series studies.

Network Meta-analysis

Network Meta-analysis

Network meta-analysis compares multiple interventions simultaneously by analyzing studies making different comparisons in the same analysis.

Network meta-analyses are best designed for:

  • Conditions with multiple interventions
  • Many combinations of direct or indirect interactions 
  • To answer more relevant clinical questions
  • To make treatment estimates for an entire treatment network instead of scanning each individual pair-wise comparison
  • To give the “full picture” to clinicians
  • Gain precision by considering all available evidence, not just (A vs. B comparisons)
  • Potential to more explicitly “rank” treatments using summary outputs

Systematic Review and Meta-analysis

systematic review answers a defined research question by collecting and summarising all empirical evidence that fits pre-specified eligibility criteria.

meta-analysis is the use of statistical methods to summarise the results of these studies.

Systematic reviews, just like other research articles, can be of varying quality. They are a significant piece of work (the Centre for Reviews and Dissemination at York estimates that a team will take 9-24 months), and to be useful to other researchers and practitioners they should have:

  • clearly stated objectives with pre-defined eligibility criteria for studies
  • explicit, reproducible methodology
  • a systematic search that attempts to identify all studies
  • assessment of the validity of the findings of the included studies (e.g. risk of bias)
  • systematic presentation, and synthesis, of the characteristics and findings of the included studies

About This Service

We offer a full package service of Systematic review & Meta-analysis (protocol development, Prospero registration, search strategy, screening process, quality assessment. risk of bias, tables of summary, data extraction, data analysis, PRISMA checklist, manuscript writing, journal selection, submission, and follow-up)  

Feel free to talk to us

SEVO-Clin is a contract research organization company. We have the expertise in regulatory requirements, and clinical trial management and have an unparalleled track record of success.


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